Table 3 Top ranking CpG sites for PTSD and MDD and at nominal P-value 0.0001
From: An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders
CpG | Chromosome | Location | Gene | Location | Diff | Coef | PV |
|---|---|---|---|---|---|---|---|
PTSD | |||||||
cg05693864 | 5 | 844184 | ZDHHC11 | Body | 0.027 | 0.25 | 1.73E−06 |
cg06182923 | 1 | 33985406 | CSMD2 | Body | −0.0312 | −0.143 | 4.73E−05 |
cg08696494 | 20 | 61447272 | COL9A3 | TSS1500 | 0.0153 | 0.0765 | 5.39E−05 |
cg25664402 | 1 | 244013908 | Intergenic | Intergenic | −0.00602 | −0.146 | 5.80E−05 |
cg05569176 | 3 | 33841973 | PDCD6IP | Body | 0.0129 | 0.164 | 7.82E−05 |
cg09370982 | 16 | 2547559 | TBC1D24 | Body | 0.00326 | 0.21 | 8.97E−05 |
cg07654569 | 8 | 79577796 | FAM164A | TSS1500 | −0.0184 | −0.311 | 9.91E−05 |
MDD | |||||||
cg19722082 | 5 | 83681563 | EDIL3 | TSS1500 | −0.0253 | −0.215 | 1.63E−06 |
cg01145119 | 8 | 144441955 | Intergenic | Intergenic | 0.0199 | 0.0843 | 2.16E−06 |
cg18155359 | 1 | 39663908 | MACF1 | Body | 0.00849 | 0.602 | 1.67E−05 |
cg08843623 | 16 | 85627648 | Intergenic | Intergenic | 0.0244 | 0.0934 | 2.14E−05 |
cg22058452 | 2 | 95662214 | Intergenic | Intergenic | 0.0038 | 0.674 | 2.73E−05 |
cg23606623 | 17 | 79373017 | BAHCC1 | TSS1500 | −0.00566 | −0.198 | 2.87E−05 |
cg27081103 | 16 | 3241159 | Intergenic | Intergenic | −0.00956 | −0.238 | 3.21E−05 |
cg06182923 | 1 | 33985406 | CSMD2 | Body | −0.0347 | −0.154 | 3.28E−05 |
cg08059112 | 19 | 2294887 | LINGO3 | 5'UTR | 0.0153 | 0.0672 | 3.71E−05 |
cg02798899 | 12 | 125028166 | Intergenic | Intergenic | 0.0161 | 0.0908 | 4.47E−05 |
cg18074834 | 7 | 143085529 | ZYX | Body | 0.0114 | 0.0514 | 4.47E−05 |
cg04654716 | 5 | 74162924 | FAM169A | TSS1500 | 0.0112 | 0.0503 | 4.55E−05 |
cg15727507 | 17 | 80981575 | B3GNTL1 | Body | 0.0164 | 0.0669 | 4.78E−05 |
cg05693864 | 5 | 844184 | ZDHHC11 | Body | 0.0233 | 0.226 | 5.42E−05 |
cg08696494 | 20 | 61447272 | COL9A3 | TSS1500 | 0.0178 | 0.081 | 5.74E−05 |
cg25810455 | 13 | 103253707 | TPP2 | Body | 0.00448 | 0.957 | 5.82E−05 |
cg03710029 | 17 | 79265601 | SLC38A10 | Body | 0.0153 | 0.063 | 5.87E−05 |
cg26628751 | 17 | 80981644 | B3GNTL1 | Body | 0.0196 | 0.0736 | 5.94E−05 |
cg04854089 | 11 | 46355137 | DGKZ | Body | 0.0106 | 0.137 | 6.59E−05 |
cg16657453 | 17 | 17735704 | SREBF1 | Body | 0.00563 | 0.454 | 6.88E−05 |
cg07970325 | 6 | 106497542 | Intergenic | Intergenic | 0.0119 | 0.0535 | 7.22E−05 |
cg12033248 | 8 | 36763165 | KCNU1 | Body | −0.00818 | −0.245 | 8.29E−05 |
cg21429107 | 8 | 144790317 | LOC100130274 | TSS200 | 0.0262 | 0.132 | 8.43E−05 |
cg16371598 | X | 72433997 | NAP1L2 | 1stExon | −0.00682 | −0.238 | 8.77E−05 |
cg09664445 | 17 | 2612406 | KIAA0664 | 5'UTR | 0.0124 | 0.0507 | 8.86E−05 |
cg23606775 | 1 | 9790616 | CLSTN1 | Body | 0.0132 | 0.0559 | 9.70E−05 |
cg01604412 | 12 | 132663741 | Intergenic | Intergenic | 0.0167 | 0.0727 | 9.83E−05 |
