Figure 1
The glucocorticoid receptor exon 1F region (GR-1F) in NR3C1. (a) All 52 5′-C–phosphate–G-3′ sites (CpGs) where methylation was measured in the present study are numbered (red: CpGs where change in methylation was associated with GR exon 1F expression change). Lowercase letters mark the promoter region, uppercase letters the GR-1F exon. Black-lined boxes represent canonical (solid) and non-canonical (dashed) NGFI-A binding sites, after McGowan et al.4 (b) NR3C1 (Chromosome 5: 142 657 496–142 815 077) from the 5′ (left) to 3′ (right) untranslated region. Boxes on the horizontal black line represent exons (gray: non-coding, green: coding sequence). The light gray box indicates a CpG island in the proximal promoter region (from 1D to 1H). (c) Six common and functional haplotypes constituted by six SNPs (rs10052957, rs10482605, rs6189, rs6195, rs41423247 and rs6198) and their frequencies in the present study. Red letters represent the minor alleles. For a scaled representation of exons 2 through 9 in relation to the first exons, see Sinclair et al.23
