Table 2 Summaries of the main analyses: associations of change in methylation (mean, number of methylated sites and functional) with trauma exposure and change in mental health problems, PTSD symptoms, GR exon 1F expression and GR-binding

From: Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment

Methylation

Trauma exposure (n=91)

Mental health problems (n=88)

PTSD symptoms (n=88)

GR exon 1F expression (n=75)

GR-binding (n=47)

 

β

t

P

β

t

P

β

t

P

β

t

P

β

t

P

Mean

0.040

3.02

0.003

0.004

1.65

0.10

0.233

1.05

0.30

−0.543

−2.63

0.011

−463

−2.56

0.014

Number of methylated loci

0.745

3.24

0.002

0.089

1.98

0.050

4.356

1.14

0.26

−0.039

−3.41

0.001

−29.9

−2.68

0.010

Functional

0.056

3.16

0.002

0.010

2.89

0.005

0.450

1.53

0.13

−0.526

−4.02

< 0.001

−317

−2.51

0.016

  1. Abbreviations: GR, glucocorticoid receptor; PTSD, posttraumatic stress disorder.
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