Table 1 Forty-seven FFAs detected by UPLC-QTOF-MS and analyzed by PLS-DA and the Mann−Whitney U-test

From: Serum fatty acid patterns in patients with schizophrenia: a targeted metabonomics study

FFA

Retention time (RT)

VIP a

P-valueb

FC c

SFAs

 C8.0

0.98

0.54

0.9406

1.03

 C12.0

2.52

1.05

0.1853

−1.18

 C14.0

4.52

0.83

0.0795

1.14

 C16.0

7.31

0.92

0.008

1.49

 C18.0

10.92

0.98

0.173

1.15

 C20.0

13.7

1.24

0.4199

1.1

 C22.0

15.36

0.83

0.6836

−1.14

 C24.0

16.52

1.02

0.0181

−1.22

MUFAs

 C12.1.cis.11

1.73

0.8

0.5958

1.25

 C14.1.cis.9

2.84

1.14

0.0034

2.25

 C16.1.cis.9

4.88

1.32

9.23E−06

2.67

 C18.1.cis.9

7.68

0.97

0.001

1.67

 C20.1.cis.11

11.12

1.33

7.97E−08

3.18

 C22.1.cis.13

13.7

1.5

7.97E−08

3.7

 C24.1.cis.15

15.27

1.77

2.05E−08

1.88

ω-6 PUFAs

 C18.2.cis.9.12

5.49

0.59

0.2364

1.34

 C20.2.cis.11.14

8.27

0.95

0.007

1.61

 C20.3.cis.8.11.14

6.25

0.92

0.0131

1.34

 C20.4.cis.5.8.11.14

5.07

1.53

0.0038

1.4

 C22.2.cis.13.16

11.67

1.1

0.0046

2.11

 C22.4.cis.7.10.13.16

7.15

0.92

0.0351

1.47

 C22.5.cis.4.7.10.13.16

6.13

1.12

0.6627

1.14

ω-3 PUFAs

 C20.5.cis.5.8.11.14.17

3.67

0.84

0.6709

1.15

 C22.3.cis.13.16.19

9.29

0.9

1

−1.01

 C22.5.cis.7.10.13.16.19

5.41

1.02

0.0204

1.5

 C22.6.cis.4.7.10.13.16.19

4.57

1.09

0.9856

1.06

TFAs

 C14.1.trans.9

3.13

1.18

0.4026

1.34

 C16.1.trans.9

5.22

0.4

0.9511

1.21

 C18.2.trans.9.12

6.19

0.87

0.4199

1.09

BCFAs

 C14.0.iso

4.23

1.19

0.4026

−1.1

 C16.0.iso

6.9

0.88

0.9511

−1.05

 C18.0.iso

10.42

0.77

0.571

1.09

OCFAs

 C15.0.iso

5.38

0.62

0.975

−1.54

 C15.0

5.82

0.67

0.9018

−1.89

 C17.1.cis.10

6.19

0.96

0.0012

1.86

 C17.0.iso

9.04

0.78

0.8718

1.02

 C17.0

8.41

1.08

0.1955

1.11

 C19.2.cis.10.13

6.83

0.79

0.1062

1.22

 C19.1.cis.10

9.36

0.8

0.0087

2.65

 C19.0

12.52

0.98

0.4199

1.07

 C21.1.cis.12

12.6

1

0.3891

1.12

 C21.0

14.62

0.54

0.975

−1.14

 C23.1.cis.14

14.24

0.29

0.8586

1.02

 C23.0

15.96

1.19

0.2436

−1.18

Others

 C18.2.CLA

5.8

1.08

0.9406

1.54

 C16.1.unknown

5.02

0.7

0.2106

1.6

 C18.3.unknown

4.15

1.12

0.9406

1.14

  1. Abbreviations: FFA, free fatty acid; MUFA, monounsaturated fatty acid; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acid.
  2. aVariable importance in the projection (VIP) was obtained from PLS-DA. The black bold values indicate VIP>1.
  3. bP-values are calculated from the nonparametric Mann−Whitney U-test. The black bold values indicate P<0.05
  4. cFold changes (FCs) were calculated from the intra-group means of FFAs, with a positive value indicating a relatively higher concentration in SCZ and a negative value indicating a relatively lower concentration compared to concentration in the healthy controls. The black bold numbers indicate that the absolute value of the FC is >1.5.
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