Figure 3
From: Linking persistent negative symptoms to amygdala–hippocampus structure in first-episode psychosis
Significant group × age interactions in surface area of the right hemisphere. Statistical maps overlaid on left hippocampal and amygdalar 3D surface rendering represent RFT-corrected P-values. Significant cluster emerged with increased surface area with age in non-PNS compared to sPNS and ePNS (P<0.01) in a posterior/ventral portion of the hippocampus. Further comparison to other groups revealed significant differences in regression slopes with age (F(3,350)=7.04, P<0.001), such that the ePNS group had a significantly negative relationship between surface area in this cluster and age compared to sPNS and non-PNS (P⩽0.001). In addition to sPNS differing from non-PNS, sPNS patients also had a significantly different positive slope compared with Controls (P<0.001). No significant interaction effects with age emerged for the right amygdala. Orientation: from left to right, surfaces depict right lateral view, followed by ventral view of hippocampal and amygdalar structures. ePNS, early persistent negative symptoms; RFT, random field theory; sPNS, persistent negative symptoms due to secondary factors.
