Figure 5 | Translational Psychiatry

Figure 5

From: Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse

Figure 5

Comparison of valproic acid (VPA) prescription and substance abuse in bipolar disorder (BD) and schizophrenia (SZ) patients. NOX2 expression is lower in BD patients prescribed with VPA compared with other BD patients and SZ patients with or without VPA prescription in both prefrontal cortex (PFC) (a) and cingulate cortex (c). NOX4 is not changed (b) and CD11b shows the same pattern as NOX2 in cingulate cortex (d). Similar analysis for substance abuse shows no difference in NOX2 and NOX4 expression in PFC (e, f) and only a difference in NOX2 expression in the cingulate cortex for BP patients with substance abuse compared with abstinent SZ patients (g). No differences in CD11b expression was detected between subgroups. The axis legend applies for the graphs of both rows. *, **ANOVA Kruskal–Wallis test followed by Dunn’s multiple comparison test.

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