Figure 4
From: Systemic inflammation enhances stimulant-induced striatal dopamine elevation
Images created from SRTM modeling at the voxel level. Analyses were performed on images aligned to a common space and averaged: (a) mean ΔBPMP+LPS image, (b) mean ΔBPMP+PBO image and (c) significance image created by paired t-testing ΔBP between drug conditions at each voxel. Voxel intensity is calculated as (1.0−P-value). Voxel values are only displayed where (1.0−P-value)>0.90. In this two-tailed t-test, no voxels were found to be significant for ΔBPMP+LPS<ΔBPMP+PBO. The sparsity of significant differences on the left side of the brain is likely due to greater observed variability in the MP+PBO condition in left ROIs (see Table 1 for ROI level values). BP, binding potential; LPS, lipopolysaccharide; MP, methylphenidate; PBO, placebo; SRTM, simplified reference tissue model.
