Figure 3 | Translational Psychiatry

Figure 3

From: Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation

Figure 3

STAT3 expression is lowered in the PBMCs of post-traumatic stress disorder (PTSD) patients. (a, b) Network showing predicted transcription factors for AGO2 and DCR1. (c) Transcript level of the three reported STAT3 variants in the PBMCs of PTSD patients as analyzed by RNA-seq (the values above the bars indicate log2 fold-change). (d) Relative abundance of STAT3 transcripts in the PBMCs of PTSD patients after analysis by qRT-PCR with 22 control and 18 PTSD samples. Here, 18S rRNA was used as an internal control. (e) Relative abundance of AGO2, DCR1 and STAT3 transcripts 72 h post-knockdown of STAT3. (f) STAT3 was knocked down using siRNA in THP-1 cells and miRNAs were quantified after 72 h. The figure shows RE of miRNAs after knockdown of STAT3. (RE: relative enrichment). PBMC, peripheral blood mononuclear cell.

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