Figure 4 | Translational Psychiatry

Figure 4

From: Decreased AGO2 and DCR1 in PBMCs from War Veterans with PTSD leads to diminished miRNA resulting in elevated inflammation

Figure 4

Cell activation leads to changes in the abundance of mature miRNAs. (a) Purity of CD4+ T cells after isolation from PBMCs of a healthy control. CD4+ T or THP-1 cells were activated/stimulated and miRNA levels were quantified after 48 h. (b) Relative expression levels of the listed miRNAs in CD4+ T cells after activation for 48 h. (c) Levels of STAT3, AGO2 and DCR1 transcripts after stimulation of THP-1 cells for 48 h. Transcript levels of all the three genes were significantly lesser compared to control. (d) miRNA relative expression levels are indicated after stimulation of THP-1 cells for 48 h.

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