Figure 2 | Translational Psychiatry

Figure 2

From: Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach

Figure 2

Interaction effect of GLRB Risk group and conditioned stimuli during fear conditioning in sample 1 (a; n=48) and sample 2 (b; n=38). During early acquisition (left), Risk allele carriers showed no (a; sample 1) CS differentiation or even inverted differentiation favoring the CS− (b; sample 2). During late acquisition (right), this pattern reversed with enhanced responding towards the CS+ compared to the CS- in the Risk group only. Risk group status was defined as carrying at least one risk allele (A allele). CS+: stimulus that was followed by the unconditioned stimulus; CS-: stimulus that was never followed by the unconditioned stimulus. R, right; L, left. Threshold at P=0.005 for illustrative purposes.

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