Figure 1
From: Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression
Proton magnetic resonance spectroscopy (1H MRS) examples voxel placement and spectra. (a) Axial and (b) sagittal localizer images showing the size and location of the anterior cingulate cortex (ACC) voxel of interest. (c) Demonstration of in vivo human GABA and Glx detection by 1H MRS in the voxel of interest: (a and b), single-voxel subspectra acquired in 15 min with the editing pulse on and off and 290 (580 total) interleaved averages; spectrum (c), difference between spectra (a and b) showing the edited brain GABA and Glx resonances; spectrum (d), model-fitting of the experimental spectrum (c) to obtain the GABA and Glx peak areas; spectrum (e), residual of the difference between spectra (c and d). GABA, γ-aminobutyric acid; Glx, glutamate+glutamine; NAA, N-acetyl-aspartate; tCho, total choline; tCr, total creatine.
