Figure 3
From: Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory
Effects of selective nectin-3 knockdown in adult-born dentate granule cells on anxiety-related behavior and cognition. (a) Schematic of experimental design. (b) Representative images showing the expression of enhanced GFP in DG, indicative of neurons infected by RV-shSCR (the control virus) or RV-shNEC (the nectin-3 knockdown virus). Scale bars=100 μm. (c–f) Nectin-3 knockdown in newly generated DG neurons had no effect on anxiety-related behavior and short-term spatial working memory. (g, h) Nectin-3 knockdown in new DG neurons impaired long-term spatial memory but not temporal order memory. *P<0.05. CT, control; DG, dentate gyrus; GFP, green fluorescent protein; KD, nectin-3 knockdown; RV, retrovirus.
