Table 1 Topics associated with PRS at an experiment-wide threshold for significance in primary analysis (left); follow-up analysis of primary associations (right)
From: Polygenic loading for major depression is associated with specific medical comorbidity
Topic | P-value tranche | Primary analysis | Excluding individuals with mood disorder diagnosis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Coefficient | 95% CI | Association P-value | Coefficient | 95% CI | Association P-value | ||
Topic 27: Ischemic Heart Disease++ | 1 × 10−2 | 0.046 | 0.022 | 0.070 | 0.000221 | 0.046 | 0.017 | 0.074 | 0.00185 |
Topic 21: Heart Failure++ | 1 × 10−4 | −0.046 | −0.070 | −0.021 | 0.000237 | −0.044 | −0.072 | −0.015 | 0.00279 |
Topic 03: Mood Disorders++ | 1 × 10−2 | 0.045 | 0.021 | 0.070 | 0.000273 | −0.010 | −0.039 | 0.018 | 0.47953 |
