Figure 4
From: The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice
JQ1 restores physiological expression of a subgroup of amyloid-associated genes. (a) Venn diagram showing the overlap between purely APP-associated changes in JQ1-associated changes in APP animals. The graphs at the top and bottom of the Venn diagram show the number of up- and downregulated genes for the two conditions. (b) Heatmap for the 107 genes in the overlap between the APP and the APP-JQ1 signature shows partial restoration of physiological expression levels compared to the APP-vehicle signature. (c) Bar graph illustrating that for a subset of 107 genes, JQ1 was able to almost fully restore physiological gene expression. The figure shows the fold changes in APP/PS1–21 vehicle animals (vs wild-type animals) in blue and the fold changes in APP/PS1–21 vehicle animals (vs APP/PS1–21 JQ1 animals) in green. (d) Salient categories represented in the 107 genes in the overlap. Both enrichment and significance are represented. BP, biological process; CC, cellular component; MF, molecular function.
