Figure 6
Chronic CORT alters the expression of the NMDA NR2A, NR2B and NR1 subunit composition independent of hBDNFVal66Met genotype. Chronic CORT treatment was found to decrease (a) NR2A, (b) NR2B and (c) NR1 subunit expression in the DHP. In the VHP, chronic CORT increased the expression of (d) NR2A and (e) NR2B but had no effect on the expression of (f) NR1. In the mPFC, the only group difference to emerge was an effect of CORT on (h) NR2B, which also increased the expression of this subunit. No modulatory effect of hBDNFVal66Met genotype emerged for the (g) NR2A or (i) NR1 subunits in this region. All data presented as mean±s.e.m.; *P<0.05, **P<0.01, ***P<0.001, and ****P<0.0001. Per group, n=13–14.
