Figure 1
From: Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice
Increased freezing and shock reactivity in Tph2-deficient mice. Paired foot shock (FS) protocol (a). Mice were exposed to a novel context for 120 s. After 120 s, a tone was paired with a FS and repeated two times with a 60 s pause. Mice were returned to the home cage 120 s after the last FS and killed 2 h later for c-Fos analysis. Freezing during fear conditioning was compared between FS+ (n=8/genotype) and FS− (n=3–4/genotype) mice (b). Shock reactivity in the FS+ and FS− groups was analyzed (c) and correlated with post-shock freezing (d). Data are shown as means±s.e.m. (b) or +s.e.m. (c). #0.1>P>0.05, **P<0.01 and ***P<0.001 compared to respective controls.
