Figure 2
From: Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice
Foot shock differentially activates the basolateral complex of amygdala in Tph2-deficient mice. Anti-parvalbumin (PV) (green) and c-Fos (red) immunofluorescent staining with DAPI (blue) of Tph2+/+, Tph2+/− and Tph2−/− mice in the lateral (LA) and basolateral (BL) nucleus of the basolateral amygdala (a). c-Fos immunostaining was analyzed in Tph2+/+, Tph2+/− and Tph2−/− mice under home cage control conditions (Ctrl) (n=5–7), mice that were placed in the conditioning context but did not receive foot shocks (FS−, n=3-4) and after the foot shock presentation (FS+, n=5–7/condition) (b). c-Fos-immunoreactive cell densities were analyzed between Ctrl, FS− and FS+ cohorts in the BL (c) and LA (d). Arrows in a indicate c-Fos ir cells in the anterior BL. Data are shown as means+s.e.m. #0.1>P>0.05, *P<0.05 and compared to respective controls. Scale bar, 100 μm (a).
