Figure 5
From: Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice
5-HT deficiency induces hyperlocomotion and escape behaviors in different contexts. Locomotor activity of Tph2+/+, Tph2+/− and Tph2−/− mice was measured over 30 min in the home cage (n=10–11/genotype) and in the open field (n=11/genotype) (a) as well as in a two-trial social interaction test (b) (n=7/genotype). Escape responses were detected as wall jumps in the open field (c). Further anxiety-like measures (n=11/genotype) included mean open-field center time (d) as well as latency to enter (e) and time in the light compartment of the light–dark box (f). Novelty-suppressed feeding (n=10–11/genotype) included latency to feed (g) as well as total feeding time (h). Social behaviors were evaluated using measures of sociability and preference for social novelty (i). Data are shown as means+s.e.m. #P<0.1, *P<0.05 and **P<0.01 compared to respective controls.
