Table 4 Associations between MDD polygenic risk scores and irritability

From: Investigating the genetic underpinnings of early-life irritability

 

OR

(95% CI)

P

ΔR2

(a) Population sample: ALSPAC

 Age 7 (N=5584)

1.09

(0.95–1.25)

0.239

0.001

 Age 10 (N=5432)

0.91

(0.79–1.05)

0.184

0.001

 Age 15 (N=3602)

1.02

(0.87–1.21)

0.785

0.0001

(b) Population sample: NCDS

 Age 7 (N=4690)

1.01

(0.92–1.12)

0.793

0.0001

 Age 11 (N=4544)

1.07

(0.98–1.17)

0.153

0.001

 Age 16 (N=4023)

0.97

(0.86–1.08)

0.536

0.0002

(c) ADHD sample: SAGE

 Age 6–18 (N=560)

1.05

(0.78–1.41)

0.763

0.0004

  1. Abbreviations: ALSPAC, The Avon Longitudinal Study of Parents and Children; MDD, major depressive disorder; NCDS, The National Child Development Study; SAGE, The Study of ADHD, Genes and Environment.
  2. MDD polygenic risk score using p-threshold <0.5. Analyses controlling for sex and 10 principle components.
Back to article page