Figure 1

Pictures of children and teeth. (a) Facial pictures: (a₁) Picture of a control ADNP-intact boy at 11 months. (a₂) Picture of full erupted dentition at 11 months of age. Patient mutation p.Leu349Argfs*47 (Table 1 (ref. 12)) at 11 months of age (2 weeks before his first birthday) with erupted first molars. Teeth erupted around 9 months of age. C₃ p.Lys831 llefs*81 (Denmark on Table 1), (a₄), 1-year-old boy, mutation, p.Lys831 llefs*81, same mutation (Belgium on Table 1, also denoted patient 4 (ref. 11)), (5) 1-year-old girl, mutation, p.Asn832Lysfs*80 (second girl from the Netherlands). (b) Pictures and shed teeth after micro-computed tomography (μCT). (b₁) (5-year-old) and (b₂; 4-year-old) pictures of the twins a₁ and a₂, respectively, at the time of first tooth shed. (b₃ and b₄) μCT images of the shed tooth (left central lower incisor) in b₁ and b₂, respectively. Warm colors represent greater thickness of the enamel. ADNP, activity-dependent neuroprotective protein.