Figure 3
From: Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children
RNAseq comparisons of ADNP-mutated human LCLs' differential expression of gene associated with tooth formation. (a) Table of mutated LCLs used for RNAseq analysis. (b) Venn diagram of differentially expressed genes (L=control, non-mutated LCL; fold-change difference=2). (c) Fifty bone-associated gene networks (genes in black or colored according to pathway legend, Stripped circles represent multiple functions) as presented by the GeneMania software (see Materials and methods) as a consequence of ADNP mutation in LCLs (P-value of pathway enrichment is presented in parenthesis). ADNP, activity-dependent neuroprotective protein; LCL, lymphoblastoid cell line; RNAseq, RNA sequencing.
