Table 1 Selected single variant and gene-burden results.

From: Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder

Gene

Marker

Consequence

P-value Faroese

P-value UK (corrected)

Support in GWAS

NOS1

rs79487279

missense_variant

4.09E−07

0.002 (0.032)

The NOS1 locus has a lead signal in schizophrenia with P-value of 1.24 × 10−6 (rs2293052)33

PITPNM2

12:123489064_C/A

missense_variant

1.93E−07

NA

In highly significant schizophrenia locus with a lead P-value of 2.19 × 10−14 (rs2851447)33

NCL

Gene test

—

5.04E−07

0.016 (0.029)

—

PIK3C2A

Gene test

—

9.46E−07

NA

PIK3C2A has a significant lead signal with P-value of 6.46 × 10−9 in a combined bipolar and schizophrenia GWAS (rs4356203)39

  1. The table summarises the most significant results of the study, both from single-variant analysis and gene-based tests. We report only results exome-wide significant in the Faroese population after Bonferroni correction (nominal P-values thresholds of 5.78 × 10−7 for the single variants and 3.12 × 10−6 for the gene tests). The P-value for the UK sample was calculated with a Fisher exact test on the genotype model with PLINK 1.9, and we report in parenthesis the P-value after Bonferroni correction. In the last column we indicate whether our finding is supported by genome-wide association studies (GWAS).
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