Figure 1

‘Risk genes’ identified by the differential expression and methylation analyses. The lists of DEGs (a) and DMPs (b) between controls versus BD patients and between controls versus offspring were compared to identify concordant genes. Thirty-three genes were concordant in the gene expression analysis, while 18 probes were concordant in the methylation analysis (annotated to 10 genes). (c) Correlation between gene expression and methylation at the MED1 and TAF15 genes. (d) Expression levels of GR signaling pathway risk genes. (e) Correlation between expression levels and family cohesion scores for the GR signaling pathway risk genes. (f) Correlation between expression levels and family conflict scores for the GR signaling pathway risk genes. **P<0.01; ***P<0.001 when compared to controls. Blue spots represent values for controls, green for offspring and red for patients. BD, bipolar disorder; DEG, differentially expressed gene; DMP, differentially methylated probes; GR, glucocorticoid receptor.