Figure 4
Glucocorticoid receptor-responsive gene expression after stimulation with dexamethasone. Lymphoblastoid cells from adult patients with bipolar disorder and controls were treated with 10−7 M for 4 h (a–c) or 48 h (d–f) and the expression of glucocorticoid receptor-responsive genes was measured (TSC22D3, PER1 and FKBP5). The levels of these genes were also measured by real-time quantitative PCR in PBMCs from children and adolescents that are healthy controls, unaffected offspring of parents with bipolar disorder and patients with pediatric bipolar disorder. *P<0.05 compared to vehicle in the same group. DEX, dexamethasone; PBMC, peripheral blood mononuclear cell; PCR, polymerase chain reaction.
