Table 1 Associations between polygenic risk scores for MDD and family history of AD at five different P-value thresholds in the GS:SFHS and UKB samples

From: Assessing the presence of shared genetic architecture between Alzheimer’s disease and major depressive disorder using genome-wide association data

MDD PGRS P-value threshold

GS:SFHS

UKB

 

Beta

95% CI

P-valuea

Beta

95% CI

P-valuea

⩽0.01

0.023

−0.016, 0.062

2.55 × 10−1

0.003

−0.031, 0.036

8.83 × 10−1

⩽0.05

0.048

0.009, 0.086

1.55 × 10−2

0.000

−0.034, 0.034

9.86 × 10−1

⩽0.10

0.037

−0.001, 0.076

6.04 × 10−2

0.010

−0.024, 0.044

5.59 × 10−1

⩽0.50

0.040

0.002, 0.079

4.17 × 10−2

0.017

−0.017, 0.051

3.30 × 10−1

⩽1.00

0.039

0.000, 0.077

4.99 × 10−2

0.016

−0.019, 0.050

3.66 × 10−1

  1. Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; GS:SFHS, Generation Scotland's Scottish Family Health Study; MDD, major depressive disorder; PGRS, polygenic risk scores; UKB, UK Biobank.
  2. aP-values shown are uncorrected for multiple testing. None of the significant P-values shown survived Bonferroni correction for multiple testing.
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