Table 2 Pathways differentially modulated in subjects exposed to SLEs (P-value<0.05)

From: Transcriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events

 

Pathway

Molecules

1

Role of IL-17A in psoriasis

CXCL8, S100A9, S100A8, CXCL1

2

Caveolar-mediated endocytosis signaling

FLNB, FLNA, ABL1, ITGAL, ITGB7

3

Natural killer cell signaling

CD247, NCR1, LAT, ZAP70, KIR3DL2, SH2D1B

4

Tumoricidal function of hepatic natural killer cells

PRF1, GZMB, ITGAL

5

Virus entry via endocytic pathways

FLNB, FLNA, ABL1, ITGAL, ITGB7

6

Cytotoxic T lymphocyte-mediated apoptosis of target cells

CD247, PRF1, GZMB

7

Superpathway of methionine degradation

FTSJ1, GOT2, AHCY

8

Role of IL-17F in allergic inflammatory airway diseases

CXCL8, CCL4, CXCL1

9

CTLA4 signaling in cytotoxic T lymphocytes

CD247, PPP2R5D, LAT, ZAP70

10

Granzyme B signaling

PRF1, GZMB

11

Crosstalk between dendritic cells and natural killer cells

PRF1, KIR3DL2, ITGAL, IL2RB

12

Methionine degradation I (to Homocysteine)

FTSJ1, AHCY

13

Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F

CCL4, CXCL1

14

T-cell receptor signaling

CD247, PTPRH, LAT, ZAP70

15

Cysteine biosynthesis III (mammalia)

FTSJ1, AHCY

16

Granzyme A signaling

PRF1, HIST1H1E

17

iCOS-iCOSL signaling in T helper cells

CD247, LAT, ZAP70, IL2RB

18

Glycine biosynthesis I

SHMT2

19

Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F

CCL4, CXCL1

20

TCA cycle II (eukaryotic)

SDHA, ACO1

21

IL-17A signaling in gastric cells

CXCL8, CXCL1

22

Cell cycle control of chromosomal replication

MCM3, CDK6

23

NADH repair

APOA1BP

24

5-aminoimidazole ribonucleotide biosynthesis I

GART

25

Glutamate degradation II and aspartate biosynthesis

GOT2

26

Aspartate biosynthesis

GOT2

27

EIF2 signaling

RPS26, RPL21, RPS21, RPL7, RPSA

28

TREM1 signaling

SIGIRR, CXCL8, NLRC3

29

Cyclins and cell cycle regulation

PPP2R5D, CDK6, ABL1

30

Proline biosynthesis I

ALDH18A1

31

l-Cysteine degradation I

GOT2

32

Phenylalanine degradation I (Aerobic)

QDPR

33

Regulation of IL-2 expression in T lymphocytes

CD247, LAT, ZAP70

34

Ceramide signaling

SMPD4, S1PR5, PPP2R5D

35

Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate

GART

36

dTMP de novo biosynthesis

SHMT2

37

Folate polyglutamylation

SHMT2

38

Regulation of eIF4 and p70S6K signaling

RPS26, PPP2R5D, RPS21, RPSA

  1. Abbreviations: IL, interleukin; SLE, stressful life event.
  2. All the 38 pathways obtained from Ingenuity pathway analysis (P-value<0.05) using as input gene set all the 207 genes significantly modulated in subjects exposed to SLEs.
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