Figure 3
PEDF mRNA changes in rat brain and blood following acute and chronic ECS. Rats were treated chronically (10 × ) or acutely (1 × ) with ECS and killed 4 h post treatment. (a) PEDF mRNA levels were significantly increased following chronic (10 × ) ECS in the hippocampus (n=7 per group) and dentate gyrus (n=7–8 per group) but not in the frontal cortex (n=7 per group), cerebellum (n=7–8 per group) or blood (n=5–6 per group). (b) PEDF mRNA levels were significantly decreased following acute (1 × ) ECS in the cerebellum (n=8 per group) but not in the hippocampus (n=8 per group), dentate gyrus (n=8 per group), frontal cortex (n=8 per group) or blood (n=6–7 per group). Data expressed as mean±s.e.m. *P<0.05 versus Sham ECS control (Student’s t-test). ECS, electroconvulsive stimulation; PEDF, pigment epithelium-derived factor.
