Table 1 Top 25 genes in high association with SZ+BP under collective inference.
Rank | Gene | AUC (95% CI) | P-value | Known association a |
|---|---|---|---|---|
1 | CSMD1 | 0.600 (0.009) | 5 × 10−19 | |
2 | CDH13 | 0.580 (0.009) | 3 × 10−15 | SZ,83 ASD,84 ADHD84 |
3 | PTPRD | 0.575 (0.009) | 3 × 10−14 | BP,37 ADHD,85 OCD86 |
4 | RBFOX1 | 0.574 (0.009) | 5 × 10−14 | ASD87 |
5 | WWOX | 0.570 (0.009) | 2 × 10−13 | ARCA88 |
6 | CSGALNACT1 | 0.565 (0.009) | 3 × 10−12 | SZ40 |
7 | FHIT | 0.564 (0.009) | 3 × 10−12 | SZ89 |
8 | MAGI2 | 0.561 (0.009) | 1 × 10−11 | SZ90 |
9 | LSAMP | 0.559 (0.009) | 3 × 10−11 | BP8 |
10 | CNTN4 | 0.558 (0.009) | 5 × 10−11 | SZ91 |
11 | DAB1 | 0.556 (0.009) | 1 × 10−10 | SZ,92 BP92 |
12 | NPAS3 | 0.555 (0.009) | 1 × 10−10 | SZ93 |
13 | LRP1B | 0.554 (0.009) | 3 × 10−10 | SZ94 |
14 | TMEM132D | 0.553 (0.009) | 4 × 10-10 | Anxiety95 |
15 | MACROD2 | 0.551 (0.009) | 8 × 10−10 | ASD96 |
16 | ASIC2 | 0.550 (0.009) | 1 × 10−9 | Fear in mice97 |
17 | PLCB1 | 0.548 (0.009) | 3 × 10−9 | SZ98 |
18 | CTNNA3 | 0.547 (0.009) | 5 × 10−9 | SZ83 |
19 | CNTNAP2 | 0.547 (0.009) | 5 × 10−9 | SZ99, BP37 |
20 | FRMD4A | 0.547 (0.009) | 6 × 10−9 | AD100 |
21 | ASTN2 | 0.545 (0.009) | 2 × 10−8 | SZ,101 ASD,102 ADHD102 |
22 | PCSK5 | 0.544 (0.009) | 2 × 10−8 | BP37 |
23 | OPCML | 0.544 (0.009) | 2 × 10−8 | SZ103 |
24 | SORCS2 | 0.543 (0.009) | 3 × 10−8 | BP36 |
25 | PTPRT | 0.543 (0.009) | 3 × 10−8 | ASD104 |
