Figure 1
From: Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation
Pharmacological inhibition of the A2AR promotes impulsivity when reward is unpredictable during DRL-conditioning. (a) Schematic of experimental design for testing impulsivity during Pavlovian-conditioning. (b) In relation to vehicle, mice-administered ZM-241385 display significantly higher magazine entries for sucrose reward during DRL-conditioning. (c) Mice treated with ZM-241385 display significantly faster reaction times to CS+ presentations relative to vehicle. (d) Schematic of experimental design for testing impulsivity during non-contingency training. (e) There were no differences detected in magazine entries between mice treated with ZM-241385 and vehicle-treated mice during non-contingency training. (f) During non-contingency training, mice treated with ZM-241385 or vehicle did not display differences in reaction times to CS-presentations. All data are expressed as mean±s.e.m. RM two-way ANOVA, #P<0.05 main effect of treatment (i.p.); *P<0.05 by Tukey’s post hoc analysis versus vehicle-treated mice. (b, c n=5–6 per treatment; e, f n=10 per treatment). DRL, differential reward of low rate; RM, repeated measures.
