Figure 3

Cathode locations. Coronal brain slices showing the location of the center of cathodes selected for crossovers after the optimization periods and those used at follow-up (seven patients) (for detailed information see Supplementary Table S2). Contacts are depicted in different shades of gray, according to their usage during the crossover phase(s) and/or at follow-up, see legend in the right bottom corner. The number in each contact refers to the patient number. Note that some patients were simultaneously stimulated with more than one contact, for example, the three contacts shown on the slice at +5.4 mm are from one patient, as indicated by the repeated patient number. On each slice, the position anterior (−) or posterior (+) to the anterior commissure is specified (top center), as well as the target area (IC/BST or ITP, indicated in italic in the bottom left corner). Instead of showing complete coronal slices, a detailed window is shown, bilaterally extending 20 mm from the midline, dorsally extending 20 mm above the intercommissural plane for the IC/BST slices, and both dorsally and ventrally extending 10 mm from this plane for the ITP slices, as depicted in the bottom left panel. In addition, a sagittal radiograph of the brain with indication of the stimulation leads is shown (bottom center panel). 3V, third ventricle; ac, anterior commissure; ALIC, anterior limb of the internal capsule; AM, anteromedial thalamic nucleus; BST, bed nucleus of the stria terminalis; Cd, caudate nucleus; DMH, dorsomedial hypothalamic nucleus; EGP, external globus pallidus; Fa, fasciculosus nucleus; fx, fornix; IC, internal capsule; IGP, internal globus pallidus; ITP, inferior thalamic peduncle; LH, lateral hypothalamic area; LS, lateral septal nucleus; LV, lateral ventricle; Pa, paraventricular hypothalamic nucleus; PRt, prereticular zone; Pu, putamen; PV, paraventricular thalamic nucleus; Rt, reticular thalamic nucleus; VA, ventral anterior thalamic nucleus; ZI, zona incerta. All images, except for the radiograph, are adapted from Mai’s Atlas of the Human Brain.³⁶