Figure 1 | Translational Psychiatry

Figure 1

From: Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats

Figure 1

Bilateral microinfusion sites and antidepressant-like action of veratridine on the FST. Neutral red staining of mPFC brain sections at anteroposterior +3.72 from bregma (left) and schematic representation of guide cannula and infusion cannula placement (right) in the (a) infralimbic cortex (IL) and (b) prelimbic cortex (PrL). (c) Bilateral microinfusion of veratridine (50 pmoles) into IL produced a rapid antidepressant-like response, as shown by decreased immobility counts and increased swimming (IL vehicle, n=7; IL veratridine, n=9). (d) Veratridine infusion into PrL produced no behavioral change on the FST (PrL vehicle, n=5; PrL veratridine, n=7). The values are expressed as mean±s.e.m. *P<0.05 and **P<0.01 versus vehicle-treated rats (Student’s t-test). FST, forced swimming test; mPFC, medial prefrontal cortex.

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