Table 1 Cohorts participating in the ENGAGE study

Cohort	Full name of cohort	N	Age (yr) mean (s.d.)	TL (T/S-ratio) mean (s.d.)	Women (%)	GRS mean (s.d.)	MMSE	DSST	BLOCK	MEMORY	STROOP	General cognition	APOE genotype
BETULA1	The Betula Study^a	163	50.9 (7.8)	1.01 (0.17)	58.3	8.5 (1.57)	×	×	×	×		×	Yes
BETULA2	The Betula Study^a	396	62.4 (14.5)	0.93 (0.15)	54.8	8.87 (1.56)	×	×	×	×		×	Yes
BETULA3	The Betula Study^a	315	60 (15)	0.97 (0.17)	54.0	8.65 (1.51)	×	×	×	×		×	Yes
ERF	Erasmus Rucphen Family (EUROSPAN)	2502	51.6 (15.8)	1.76 (0.36)	55.6	8.65 (1.57)				×	×	×	Yes
FITSA	The Finnish Twin Study on Ageing	429	68.6 (3.4)	0.9 (0.19)	100.0	8.52 (1.46)	×	×					Yes
Gender	Sex differences in health and aging	466	74.5 (2.6)	0.68 (0.15)	49.0	8.43 (1.34)		×	×	×		×	Yes
HRS	Health and Retirement Study	4117	70.4 (9.4)	1.3 (0.3)	58.0	8.6 (1.52)	×			×		×
LBC1936	Lothian Birth Cohort	999	69.6 (0.8)	1.3 (0.5)	49.0	8.36 (1.56)	×	×	×	×		×	Yes
LLS1	Leiden Longevity Study 1	2305	59.2 (6.8)	1.46 (0.26)	54.8	8.47 (1.52)		×		×	×		Yes
LLS2	Leiden Longevity Study 2	868	93.3 (2.6)	1.28 (0.22)	61.6	8.44 (1.57)	×						Yes
NSHD	National Survey of Health and Development	2425	53 (0)	1.54 (0.91)	50.0	8.55 (1.4)				×		×	Yes
NTR	Netherlands Twin Register	200	40.3 (16.4)	2.72 (0.56)	66.5	8.5 (1.56)						×
QIMR	Twin studies at the Queensland Institute of Medical Research	1280	14.1 (2.4)	3.7 (0.6)	52.6	8.5 (1.5)						×
SATSA	Swedish Adoption/Twin Study of Aging	587	68.8 (9.6)	0.76 (0.27)	58.0	8.45 (1.45)		×	×	×		×	Yes

Abbreviations: BLOCK, block design test; CHARGE, Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium; DSST, digit symbol substitution test; ENGAGE, European Network for Genetic and Genomic Epidemiology; GRS, genetic risk score; MEMORY, verbal memory or picture learning test; MMSE, mini-mental state exam; STROOP, stroop color word task interference score; TL, telomere length; Yr, year.
^aBETULA1 and BETULA2-3 were genotyped at two different facilities.

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