Table 2 Performance metrics for the four common pathways across the three ethnically distinct cohorts

From: Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations

Point estimate (95% CI)

Ubiquitin-mediated proteolysis

Serotonergic synapse

Hedgehog signaling

Adipocytokine signaling pathway

Renin secretion

 

EA

AA

CH

EA

AA

CH

EA

AA

CH

EA

AA

CH

EA

AA

CH

Sensitivity

0.530

(0.526–0.534)

0.515

(0.508–0.522)

0.519

(0.514–0.523)

0.522

(0.519–0.525)

0.506

(0.499–0.513)

0.491

(0.486–0.496)

0.513 (0.509–0.516)

0.510 (0.503–0.517)

0.495 (0.491–0.500)

0.520 (0.517–0.523)

0.515 (0.508–0.522)

0.491 (0.486–0.496)

0.524 (0.521–0.527)

0.508 (0.501–0.516)

0.490 (0.485–0.494)

Specificity

0.490

(0.487–0.493)

0.505

(0.498–0.512)

0.506

(0.502–0.511)

0.491

(0.487–0.494)

0.508

(0.501–0.515)

0.524

(0.519–0.529)

0.504 (0.500–0.508)

0.504 (0.496–0.512)

0.522 (0.518–0.527)

0.505 (0.501–0.508)

0.507 (0.499–0.514)

0.525 (0.520–0.529)

0.492 (0.488–0.495)

0.505 (0.497–0.513)

0.524 (0.520–0.529)

AUC

0.515

(0.513–0.517)

0.518

(0.514–0.523)

0.520

(0.517–0.523)

0.508

(0.506–0.510)

0.509

(0.505–0.514)

0.512

(0.509–0.515)

0.511 (0.509–0.513)

0.511 (0.505–0.516)

0.511 (0.508–0.515)

0.517 (0.514–0.519)

0.514 (0.509–0.518)

0.509 (0.506–0.512)

0.511 (0.509–0.514)

0.508 (0.503–0.514)

0.511 (0.508–0.514)

Accuracy

0.512

(0.510–0.515)

0.510

(0.506–0.515)

0.512

(0.510–0.515)

0.509

(0.507–0.510)

0.507

(0.503–0.511)

0.508

(0.505–0.511)

0.509 (0.507–0.511)

0.507 (0.502–0.512)

0.509 (0.506–0.512)

0.513 (0.511–0.515)

0.511 (0.506–0.515)

0.509 (0.506–0.511)

0.510 (0.508–0.512)

0.509 (0.502–0.512)

0.508 (0.505–0.511)

Odds ratio

1.087

(1.069–1.104)

1.104

(1.065–1.144)

1.113

(1.088–1.138)

1.057

(1.041–1.073)

1.072

(1.038–1.107)

1.070

(1.043–1.098)

1.073 (1.056–1.091)

1.077 (1.036–1.117)

1.080 (1.054–1.105)

1.108 (1.09–1.127)

1.109 (1.069–1.150)

1.072 (1.046–1.098)

1.069 (1.053–1.086)

1.080 (1.036–1.124)

1.065 (1.041–1.090)

Adjusted-P

1.07 × 10−7

0.0139

0.00242

0.000285

0.0492

0.00420

1.55 × 10−7

0.00615

2.41 × 10−5

2.89 × 10−14

0.0103

0.0121

3.03 × 10−8

0.0139

0.00597

Nagelkerke R2a

0.0005

—

0.0057

0.0017

—

0.0015

0.0003

—

0.0033

0.0011

—

0.0005

0.0010

—

0.0012

  1. Abbreviations: AA, African-American cohort; AUC, area under the curve; CH, Han Chinese cohort; EA, European-American cohort.
  2. aRefer to the Supplementary Materials for details.
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