Figure 1
From: Altered expression of histamine signaling genes in autism spectrum disorder
Magnitude of altered expression of histamine-related genes in autism spectrum disorder (ASD). (a) The absolute log2 fold changes of gene expression between ASD subjects and control subjects within the original data set are shown on the x axis for all Ensembl genes evaluated in this differential expression analysis, while the y axis shows the frequency, or number of genes with each log2 fold change value. The x axis shown is limited to changes between 0 to 0.2 to allow easier evaluation of the genes of interest, however, the full range of absolute log2 fold changes was 4.9 × 10−6 to 1.2. This indicates the extent to which genes showed differential expression, regardless of the direction of change. The red lines indicate the absolute log2 fold changes of the histamine-related genes of interest. (b) The absolute log2 fold changes of gene expression between the ASD subjects and the control subjects within the replication data set are shown on the x axis for all Ensembl genes evaluated in this differential expression analysis, while the y axis shows the frequency, or number of genes with each log2 fold change value. The x axis shown is limited to changes between 0 to 0.2 to allow easier evaluation of the genes of interest, however, the full range of absolute log2 fold changes was 8.7 × 10−7 to 6.02. Again, the red lines indicate the absolute log2 fold changes identified for the genes of interest.
