Figure 6
Schematic representation of the effect of fenofibrate on genes affecting lipid and lipoprotein metabolism and mitochondrial functions, as well as the role of the transcription factors Esrrg, Pparα, the coactivators Pgc1a and Pgc1b and Arid5b in this process. Direct effects may involve transcriptional activation of the Pparα gene by Esrrg, stabilization of Pparα by ligands, activation by coactivators and synergistic interactions between Esrrg and Pparα on the promoters of fenofibrate-inducible genes. Indirect effects may involve the Esrrg-mediated negative regulation of Arid5b expression, which may influence Pparα gene expression.
