Table 2 Grade 3–4 toxicity, dose delay, dose reduction or discontinuation after the first two cycles (outcome A) and grade 3–4 toxicity after all cycles (outcome B) in relation to the number of treatment cycles

From: Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer

 

All

Toxicity (%)

No toxicity (%)

OR (95% CI)

P-valuea

Outcome A

 1–8 cycles

49

22

(45)

27

(55)

9.37

(2.92–30.1)

<0.001

 9–13 cycles

41

9

(22)

32

(78)

3.23

(0.92–11.4)

 

 >13 cycles

50

4

(8)

46

(92)

Ref.

  

Outcome B

 1–8 cycles

49

27

(55)

22

(45)

1.23

(0.56–20.6 )

0.07

 9–13 cycles

41

13

(32)

28

(68)

0.46

(0.20–7.65)

 

 >13 cycles

50

25

(50)

25

(50)

Ref.

  
  1. aFisher's exact test.
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