Table 4 Cox regression analyses of the three-gene predictive index percentile, as a continuous variable, for published DNA microarray data from 40 metastatic gastric cancer patients treated with either FU-based chemotherapy or cisplatin/irinotecan combination chemotherapy

From: Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy

 

Overall survival

 

P-value

HR (95% CI)

Univariate

  

 Three-gene predictive index percentile

0.047

1.014 (1.000–1.027)

Multivariate

 Three-gene predictive index percentile

0.026

1.017a (1.002–1.032)

 Performance status ⩾1

0.028

3.008 (1.129–8.016)

 Ageb

0.766

0.995 (0.961–1.030)

 Male

0.538

1.359 (0.512–3.605)

 FU-based chemotherapy regimenc

0.744

0.854 (0.332–2.199)

  1. Abbreviations: CI, confidence interval; FU, fluorouracil; HR, hazard ratio.
  2. aAdjusted HR for each percentile increase in three-gene predictive index percentile. For example, a predictive index percentile of 100 (the highest predictive index) is associated with an HR of 5.4 (=1.017100), compared with a predictive index percentile of 0 (the lowest predictive index).
  3. bAs a continuous variable.
  4. cAs compared with the irinotecan/cisplatin combination chemotherapy regimen.
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