Table 3 Summary of meta-analysis
Toxicity | Compared genotype | Group | No. of studies | No. of participants | Odds ratios (ORs) 95% confidence intervals (CI) | P-value | Test for heterogeneity | |
|---|---|---|---|---|---|---|---|---|
P-value | I2(%) | |||||||
Neutropenia | *28/*28 vs *1/*1 | Total | 13 | 1095 | 4.79 [3.28, 7.01] | <0.00001 | 0.20 | 22 |
+5FU subgroup | 12 | 932 | 4.67 [3.11, 7.00] | <0.00001 | 0.14 | 30 | ||
−5FU subgroup | 3 | 163 | 5.87 [1.97, 17.42] | <0.001 | 0.41 | 0 | ||
High IRI subgroup | 9 | 764 | 4.64 [2.88, 7.17] | <0.00001 | 0.06 | 44 | ||
Low IRI subgroup | 6 | 331 | 6.37 [2.69, 10.71] | <0.00001 | 0.76 | 0 | ||
*1/*28 vs 1/*1 | Total | 14 | 1819 | 1.90 [1.44, 2.51] | <0.00001 | 0.98 | 0 | |
+5FU subgroup | 13 | 1573 | 1.87 [1.39, 2.51] | <0.0001 | 0.93 | 0 | ||
−5FU subgroup | 3 | 246 | 2.18 [0.91, 5.22] | 0.08 | 0.85 | 0 | ||
High IRI subgroup | 9 | 1189 | 1.85 [1.32, 2.58] | 0.0003 | 0.98 | 0 | ||
Low IRI subgroup | 7 | 630 | 2.01 [1.21, 3.34] | 0.007 | 0.61 | 0 | ||
*28/*28 vs *1/*28 or *1/*1 | Total | 14 | 2015 | 3.44 [2.45, 4.82] | <0.00001 | 0.15 | 26 | |
+5FU subgroup | 13 | 1740 | 3.40 [2.37, 4.88] | <0.00001 | 0.14 | 29 | ||
−5FU subgroup | 3 | 275 | 3.70 [1.46, 9.40] | 0.006 | 0.20 | 38 | ||
High IRI subgroup | 9 | 1311 | 3.34 [2.21, 5.05] | <0.00001 | 0.02 | 54 | ||
Low IRI subgroup | 7 | 704 | 3.63 [2.02, 6.53] | <0.00001 | 0.96 | 0 | ||
Diarrhoea | *28/*28 vs *1/*1 | Total | 13 | 1122 | 1.84 [1.24, 2.72] | 0.002 | 0.15 | 27 |
+5FU subgroup | 12 | 913 | 1.78 [1.16, 2.75] | 0.009 | 0.07 | 41 | ||
−5FU subgroup | 4 | 209 | 2.09 [0.83, 5.26] | 0.12 | 0.56 | 0 | ||
High IRI subgroup | 8 | 774 | 2.37 [1.39, 4.04] | 0.002 | 0.31 | 15 | ||
Low IRI subgroup | 6 | 348 | 1.41 [0.79, 2.51] | 0.24 | 0.12 | 42 | ||
*1/*28 vs 1/*1 | Total | 13 | 1794 | 1.20 [0.93, 1.56] | 0.16 | 0.55 | 0 | |
+5FU subgroup | 12 | 1472 | 1.19 [0.89, 1.58] | 0.25 | 0.46 | 0 | ||
−5FU subgroup | 4 | 322 | 1.28 [0.71, 2.30] | 0.41 | 0.44 | 0 | ||
High IRI subgroup | 8 | 1201 | 1.39 [0.97, 1.98] | 0.07 | 0.65 | 0 | ||
Low IRI subgroup | 6 | 593 | 1.02 [0.70, 1.50] | 0.91 | 0.36 | 8 | ||
*28/*28 vs *1/*28 or *1/*1 | Total | 13 | 1980 | 1.71 [1.18, 2.47] | 0.005 | 0.29 | 14 | |
+5FU subgroup | 12 | 1626 | 1.67 [1.11, 2.52] | 0.01 | 0.17 | 28 | ||
−5FU subgroup | 4 | 354 | 1.85 [0.77, 4.43] | 0.17 | 0.53 | 0 | ||
High IRI subgroup | 8 | 1317 | 2.04 [1.23, 3.38] | 0.006 | 0.41 | 3 | ||
Low IRI subgroup | 6 | 663 | 1.41 [0.82, 2.43] | 0.21 | 0.20 | 31 | ||
