Figure 4 | The Pharmacogenomics Journal

Figure 4

From: Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

Figure 4

Four early-response signatures were validated in rat. (a) The four groups of rat samples are significantly associated with cytotoxicities measured by DNA content. NGTX: non-genotoxic carcinogens. The three asterisks (***) indicate that the P-value of comparing DNA content of two adjacent groups is smaller than 0.001. (b) Venn diagrams comparing compounds that induce progressive profiles in human and rat, and comparing frequently induced genes in the two species. (c) Temporal patterns of the four human orthologs that are also signatures in rat. See caption of Figure 3d for legends.

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