Figure 5 | The Pharmacogenomics Journal

Figure 5

From: Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

Figure 5

Dynamics of the early-response network is encoded by its structure. (a) Dynamics of the network in human (left) and rat (right), showing their arithmetic mean (lines) and standard errors of the mean (error bars). (b) The Boolean network model. Four genes are connected with thick lines embodying binary interactions. Solid-arrow tip: positive trans-activation; solid-circle tip: indirect activation; bar: transcriptional inhibition. Biological functions are given in rectangular nodes, with genes connected to them with thin lines. Solid-circle tips indicate positive effects, and bars indicate negative effects. Only gene nodes and their interactions are used for modelling and simulation. (c) Simulated dynamics using the Boolean network model with the initial state IS1 (top) and IS2 (bottom). Random noise is added to facilitate visualization.

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