Figure 2 | The Pharmacogenomics Journal

Figure 2

From: Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

Figure 2

Polymorphisms associated with response to anti-TNF. Thirty-seven functional single nucleotide polymorphisms (SNPs) in 26 genes were successfully genotyped and 19 SNPs in 14 genes were associated with response to antitumor necrosis factor-α (TNF-α) therapy among patients with Crohn’s disease (CD), ulcerative colitis (UC) or CD and UC combined. The 19 SNPs associated with response were in genes involved in regulation of NFκB through the Toll-like receptor (TLR) pathways (TLR2, TLR4, TLR9, LY96 (MD-2), CD14 and MAP3K14 (NIK)), TNF-α signaling (TNFA (TNF-α), TNFRSF1A (TNFR1) and TNFAIP3 (A20)) or cytokines regulated by NFκB (IL1B, IL1RN, IL6, IL17A and IFNG).

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