Table 1 Clinical characteristics of premenopausal patients
Singapore (n=164) | Lebanon (n=78) | POSH (n=345) | Overall (n=587) | P-valuea | |||||
|---|---|---|---|---|---|---|---|---|---|
No. of patients | % | No. of patients | % | No. of patients | % | No. of patients | % | ||
Follow-up, years | <0.001 | ||||||||
Median | 4.0 | 4.1 | 6.4 | 5.5 | |||||
Range | 1.3–14.2 | 1.9–8.5 | 1.2–11.6 | 1.2–14.2 | |||||
Age at diagnosis, years | <0.001 | ||||||||
Median | 47.0 | 43.0 | 37.5 | 39.1 | |||||
Range | 30.0–59.0 | 24.0–51.0 | 22.0–41.0 | 22.0–59.0 | |||||
BMI | <0.001 | ||||||||
⩽30 | 153 | 93.3 | 62 | 79.5 | 272 | 78.8 | 487 | 82.9 | |
>30 | 10 | 6.1 | 16 | 20.5 | 65 | 18.8 | 91 | 15.5 | |
Unknown | 1 | 0.6 | 8 | 2.3 | 9 | 1.5 | |||
Ethnicity | <0.001 | ||||||||
Caucasian | 320 | 92.8 | 320 | 54.5 | |||||
Asian | 164 | 100 | 5 | 1.4 | 169 | 28.8 | |||
African | 15 | 4.3 | 15 | 2.6 | |||||
Middle Eastern | 78 | 100 | 78 | 13.3 | |||||
Unknown | 5 | 1.4 | 5 | 0.9 | |||||
Tumor size (cm) | 0.004 | ||||||||
⩽2 | 95 | 57.9 | 30 | 38.5 | 174 | 50.4 | 299 | 50.9 | |
2–5 | 58 | 35.4 | 35 | 44.9 | 142 | 41.2 | 235 | 40.0 | |
>5 | 11 | 6.7 | 13 | 16.7 | 20 | 5.8 | 44 | 7.5 | |
Unknown | 9 | 2.6 | 9 | 1.5 | |||||
Nodal status | 0.08 | ||||||||
Negative | 92 | 56.1 | 40 | 51.3 | 159 | 46.1 | 291 | 49.6 | |
Positive | 69 | 42.1 | 38 | 48.7 | 184 | 53.3 | 291 | 49.6 | |
Unknown | 3 | 1.8 | 2 | 0.6 | 5 | 0.9 | |||
Grading | 0.21 | ||||||||
G1 | 14 | 17.9 | 38 | 11.0 | 52 | 8.9 | |||
G2 | 35 | 44.9 | 178 | 51.6 | 213 | 36.3 | |||
G3 | 27 | 34.6 | 125 | 36.2 | 152 | 25.9 | |||
Unknown | 164 | 100 | 2 | 2.6 | 4 | 1.2 | 170 | 29.0 | |
Hormone receptor status | 0.472 | ||||||||
(ER or PR) Positive | 164 | 100 | 78 | 100 | 340 | 98.6 | 582 | 99.1 | |
(ER and PR) Negative | 3 | 0.9 | 3 | 0.5 | |||||
Unknown | 2 | 0.6 | 2 | 0.3 | |||||
HER2 status | 0.252 | ||||||||
Positive | 43 | 26.2 | 18 | 23.1 | 66 | 19.1 | 127 | 21.6 | |
Negative | 112 | 68.3 | 60 | 76.9 | 158 | 45.8 | 330 | 56.2 | |
Unknown | 9 | 5.5 | 121 | 35.1 | 130 | 22.1 | |||
Chemotherapy | 0.001 | ||||||||
Yes | 143 | 87.2 | 69 | 88.5 | 261 | 75.7 | 473 | 80.6 | |
No | 21 | 12.8 | 9 | 11.5 | 84 | 24.3 | 114 | 19.4 | |
CYP2D6 phenotypes | <0.001 | ||||||||
PM/PM | 4 | 5.1 | 30 | 8.7 | 34 | 5.8 | |||
hetEM/IM | 129 | 78.7 | 37 | 47.4 | 205 | 59.4 | 371 | 63.2 | |
EM/UM | 33 | 20.1 | 37 | 47.4 | 110 | 31.9 | 180 | 30.7 | |
Unknown | 2 | 1.2 | 2 | 0.3 | |||||
