Table 2 Generalised linear models showing differences in HV (cm per year) by genotype and SDE group

From: Effect of summer daylight exposure and genetic background on growth in growth hormone-deficient children

Gene

SNP ID

Model

Genotype

HV (cm per year) SDE ⩽14.3 h (n of patients=23)

HV (cm per year) SDE >15.5 to <14.3 h (n of patients=73)

HV (cm per year) SDE ⩾15.5 h (n of patients=22)

SDE P-value

Genotype P-value

Interaction P-value

GRB10

rs1024531

Allele*

AA

(13)

(36)

(12)

0.019

0.001

<0.0001†

    

9.7 (8.7, 10.8)

9.0 (8.4, 9.6)

10.0 (8.7, 11.0)

   
   

GG & GA

(10)

(37)

(10)

   
    

8.0 (6.8, 9.3)

7.7 (7.0, 8.3)

9.8 (8.6, 11.1)

   
 

rs12536500

Allele*

CC

(16)

(43)

(12)

0.015

0.001

<0.0001†

    

9.5 (8.5, 10.5)

9.0 (8.3, 9.5)

10.0 (8.7, 11.0)

   
   

TT & TC

(7)

(30)

(10)

   
    

7.8 (6.4, 9.3)

7.5 (6.8, 8.3)

9.8 (8.6, 11.1)

   
 

rs933360

Allele*

TT

(14)

(46)

(15)

0.014

0.044

0.008†

    

9.8 (8.8, 10.9)

8.5 (8.0, 9.1)

10.5 (9.5, 11.6)

   
   

TC & CC

(9)

(27)

(7)

   
    

7.7 (6.4, 9.0)

8.0 (7.2, 8.8)

8.7 (7.2, 10.1)

   

IGFBP-3

rs3110697

Allele**

GG & GA

(20)

(60)

(18)

   
    

9.1 (8.2, 10.0)

8.6 (8.1, 9.1)

10.0 (9.1, 11.0)

0.031

0.025

0.009†

   

AA

(3)

(13)

(4)

   
    

8.4 (6.1, 10.6)

7.3 (6.1, 8.4)

8.4 (5.7, 11.1)

   

TGF-α

rs958686

Allele*

CC

(3)

(10)

(2)

   
    

9.3 (7.0, 11.7)

8.5 (8.1, 8.9)

11.4 (8.0, 14.8)

0.027

0.152

0.015†

   

GG & GC

(20)

(63)

(20)

   
    

9.3 (8.5, 10.1)

7.5 (6.3, 8.5)

9.0 (8.2, 9.9)

   

CYP19A1

rs10459592

Allele*

GG

(7)

(14)

(7)

   
    

10.7 (9.2, 12.1)

9.4 (8.4, 10.4)

10.8 (9.3, 12.1)

0.041

0.039

0.026†

   

TT & TG

(16)

(59)

(15)

   
    

8.3 (7.3, 9.2)

8.1 (7.6, 8.6)

9.6 (8.5, 10.6)

   

TP53

rs2909430

Allele*

TT

(18)

(48)

(18)

   
    

9.1 (8.2, 10.0)

8.6 (8.1, 9.2)

10.3 (9.3, 11.3)

0.028

0.128

0.033†

   

TC & CC

(5)

(25)

(4)

   
    

8.8 (7.0, 10.5)

7.8 (7.0, 8.6)

8.1 (6.1, 10.1)

   
  1. Abbreviations: CI, confidence intervals; HV, height velocity; n, number of patients; SDE, summer daylight exposure. SDE had a significant effect on HV in all genotype groups, whereas genotypes for GRB10, IGFBP-3 and CYP19A1, but not TGF-α and TP53 had an effect on HV across the SDE groups. However, a significant interaction between the genotype and SDE was present for all the SNPs (†).
  2. HV (cm per year) is presented as mean and 95% CIs in parentheses. Allele**=major allele dominant, Allele*=major allele recessive.
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