Table 1 Literature support for 20 significant (TF, treatment) associations at FDR ≤0.1 where the TF is associated with ≤5 treatments and the treatment is associated with ≤10 TFs
From: Computational discovery of transcription factors associated with drug response
Association no. | Treatment | TF | Literature evidence |
|---|---|---|---|
1 | Cisplatin | EGR1 | Direct |
2 | Cisplatin | STAT1 | Direct |
3 | Docetaxel | FOXM1 | Direct |
4 | Radiation | STAT3 | Direct |
5 | Cisplatin | SMARCB1 | Direct |
6 | Cisplatin | BCL3 | Direct |
7 | TCN | EZH2 | Indirect |
8 | Gemcitabine | SETDB1 | Indirect |
9 | Docetaxel | KDM5B | Indirect |
10 | Hypoxia | ARID3A | Indirect |
11 | Carboplatin | MBD4 | Indirect |
12 | Cisplatin | TFAP2C | Indirect |
13 | Docetaxel | BCL3 | Indirect |
14 | Everolimus | TAF7 | None found |
15 | NAPQI | TFAP2C | None found |
16 | TCN | ARID3A | None found |
17 | TCN | STAT1 | None found |
18 | Metformin | HMGN3 | None found |
19 | Metformin | ZKSCAN1 | None found |
20 | TCN | SETDB1 | None found |
