Figure 2 | The Pharmacogenomics Journal

Figure 2

From: Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines

Figure 2

(a) Heatmap of the 389 Pharmacogenomics Research Network pharmacogenes’ expression (Fragments per Kilobase of Exon Mapped, FPKM) across 90 samples. Samples are arranged horizontally, grouped by tissue. Pharmacogenes are arranged vertically, grouped by clusters identified by k-means clustering; clusters are indicated by colors along the left side of the heatmap. Selected clusters show (b) genes expressed at low levels across all samples (ABCB5, ABCC12, ABCC8, ADH7, ADRB3, ALDH3A1, BDNF, CACNA1S, CFTR, CHRM3, CHST13, CHST4, CHST5, CHST6, CHST8, CRHR1, CYP11B1, CYP11B2, CYP26A1, CYP26C1, CYP2A13, CYP2F1, CYP2S1, CYP4F8, CYP4Z1, CYP7A1, DRD1, DRD2, DRD3, DRD4, DRD5, ESR2, FMO6P, GNB3, GRM3, GSTA3, GSTA5, GSTT2, HTR1A, HTR2A, IL28B, KCNE2, MMP3, OPRM1, P2RY1, PNMT, PRSS53, RYR1, SCN3B, SLC10A2, SLC22A13, SLC22A14, SLC22A16, SLC22A4, SLC28A2, SLC28A3, SLC6A3, SLC6A4, SLCO1A2, SLCO6A1, SULT1A3, SULT4A1, TPH1, TPH2, TPSG1, UGT1A10, UGT1A5, UGT1A8, UGT2B11 and UGT2B28) (c) genes highly expressed across all samples (ADD1, ADH5, ALDH2, CYB5A, CYB5R3, GSTK1, GSTO1, GSTP1, HLA-B, RPL13 and SOD2) or genes expressed at higher levels in (d) liver (ABCB4, ABCC2, ADH1A, ADH4, APOA4, APOB, CYP2A6, CYP2B6, CYP2C18, CYP2C8, CYP2C9, CYP2D6, CYP2J2, CYP3A4, CYP3A5, CYP4F11, CYP8B1, F2, F5, MAT1A, NAT2, PON1, PON3, SERPINA7, SLC22A1, SLCO1B1, SLCO1B3, SULT2A1, UGT1A1, UGT1A4, UGT2B10, UGT2B15 and UGT2B4), (e) kidney (ABP1, FMO1, GSTA2, GSTO2, HSD11B2, SLC13A1, SLC13A3, SLC22A11, SLC22A12, SLC22A2, SLC22A6, SLC22A8, SULT1C2 and UGT8), or (f) heart (ADRB1, CACNA1C, KCNH2, NPPB, RYR2 and SCN5A). Gene names are listed in order from top to bottom in each cluster in the figure. Plot drawn using R package gplots. LCL, lymphoblastoid cell line.74

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