Figure 1 | The Pharmacogenomics Journal

Figure 1

From: Integrated Drug Expression Analysis for leukemia: an integrated in silico and in vivo approach to drug discovery

Figure 1

Flowchart of integrated screening pipeline. Drug treatment profiles from HL60 cell lines were integrated with acute myeloid leukemia (AML) patient gene expression profiles (GEPs) to derive drug regulatory score (DRS) profiles for each drug. Survival analysis of DRS profiles was implemented to identify drugs associated with patient survival. Selected candidates were then validated in an AML mouse model.

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