Figure 4 | The Pharmacogenomics Journal

Figure 4

From: Integrated Drug Expression Analysis for leukemia: an integrated in silico and in vivo approach to drug discovery

Figure 4

Correlation of trichostatin A (TSA) with drug IC50 and mRNA expression across 102 blood-derived Genomics of Drug Sensitivity (GDSC) cell lines. (a) Correlation of TSA drug regulatory score (DRS) with IC50 of 125 drugs from the GDSC database. (b) TSA DRS is anticorrelated with HDAC2 mRNA expression. (c) TSA DRS is correlated with ABT-263 (Bcl2 inhibitor) IC50. (d) TSA DRS is correlated with AZD6244 (MEK inhibitor) IC50. (e) TSA DRS is correlated with MEK mRNA expression.

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