Figure 1
Overview of the opioid receptor genetic pattern of the present patients (n=30 and 28 pain patients with high and average opioid dosage, respectively). The denominations of gene loci where variants have been detected is given at the bottom of the figure. (Top) Bar plot of the frequency of carriers of single-nucleotide polymorphisms (SNPs), with bar lengths indicating the percentage of patients carrying a variant allele (either heterozygously or homozygously); bars in the upper direction (yellow) show the high opioid patients (n=30) and bars directed toward the bottom (dark gray) show the controls (n=28). (Bottom) Matrix plot of the occurrence of variants (columns) per patient (lines; color coding is white: wild type, yellow: heterozygous, red: homozygous rare allele), separated by gaps for the two groups of patients and for the four opioid receptor genes (OPRD1, OPRM1, OPRK1 and SIGMAR1) from the left to the right; the codes at the right are the patient’s codes left in the figure for potential data validation purposes). For better visibility, the variants are numbered and the abscissa details are given in an enlarged version in the Supplementary Materials (DetailedAbscissa_Figure1.pdf).
