Table 3 Performances of selected classifiers to predict a patient with high opioid dosing

From: Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses

Classifier

Group difference (P-uncorrected)*

No. of genes

Sensitivity (%)

Specificity (%)

PPV (%)

Accuracy (%)

No. of 7 independent samples correct

Chr6:154360797-SNV

P=0.589

1

13.9

87

51

50.6±5

0

Chr6:154451812-SNV

0.00049

1

2.9

100

29

51.5±2

0

Chr8:54147491-SNV

0.000278

1

10.5

92.2

52

51.4±5

4

Regression

—

6

67.7

55.7

60

61.7±6

4

CART

—

12

92.6

56.1

68

74.4±4

3

Clustering+kNN classifier

—

152

75.3

73.5

74

74.4±7

5

ABC analysis+clustering+kNN classifier

—

34

93.7

67.4

74

80.6±4

4

  1. Abbreviations: CART, classification and regression tree; kNN, k-nearest neighbor; PPV, positive predictive value; SNV, single-nucleotide variation.
  2. χ2 test: the α-corrected significance level was 0.000649351.
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