Figure 2
The hypermethylation-mediated downregulations of genes in the HCT-8/5-fluorouracil (5-FU) cells have frequent protein–protein interaction (PPI) links with 5-FU activity-related genes. 5-FU activity-related genes: genes involved in 5-FU transport, metabolism and other downstream effects (such as DNA repair, apoptosis and cell cycle regulation) in the public databases. The green nodes denote 5-FU activity-related related genes. The yellow nodes denote the hypermethylation-mediated downregulations of genes in the HCT-8/wild-type (WT) compared with the HCT-8/5-FU cells. The red nodes were overlapped between the two kinds of genes.
